I've just recently seen the first few episodes. I don't get Showtime, WB, UPN, HBO or any of those american channels that show the good shows where I live so I have to rely on Bittorrent to get a lot of TV shows.
So I downloaded the few episodes of Weeds and watched it and was pleasantly surprised. The main character is a very likable person and the kind of mother I wish I had. It has an original but believable plot to say the least. But I totally agree with your description of it when you say Trailer Park Boys/Desperate Housewives.
Even the youngest son is likable and I generally hate TV shows with main characters who are dumb little kids, but this kid is just down right evil and creative.