I'd disagree. I doubt that Naruto (the anime) will be so different as to not do what is expected. And that is to have Naruto become Hokage in the end.
I'll also say this, which I am almost 100% sure it is going to happen... That is, that Naruto, Sasuke, and Sakura will become exact copies of the Legendary Sannin. Meaning, that once grown up, they will be the Legendary Sannin of their generation. It's almost obvious in the anime already. Naruto is constantly being compared to Jiraiya as a kid, Sasuke is following in Orochimaru's footsteps, and Tsunade is currently training Sakura as a expert medical ninja (not to mention Sakura is just as hotheaded as Tsunade).
So, when it happens, remember who said it first.

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