There is only one anime that has ever made me cry... Grave Of The Fireflies. O_O
I have only watched it once and blubbered like a baby! I can't bring myself to ever watch it again. LOL! Even the cover of dvd makes me tear up, just thinking about it. I am a wuss, I know!
Other anime movies or series have their sad points, yet never make me tear up, just frown excessively. This was the only anime ever that broke me. XD