Drinking?

Les Gouttes de Dieu (Kami no Shizuku) is a manga where the central focus of the story is on wine.

Les Gouttes de Dieu - Wikipedia, the free encyclopedia
Kami no Shizuku (manga) - Anime News Network
Kami no Shizuku - DramaWiki

I'm not sure if this is what you had in mind when you asked about drinking manga, but it's definitely worth checking out at least.

Grumble Grumble Grumble

Now there is a Anime series (based on a Manga series) that is completely about recreational drug use...

Bartender (TV) - Anime News Network:
Bartender (manga) - Wikipedia, the free encyclopedia:
(and who opened up a old thread here???)

lol Hmmm i was gonna say bartender lol but Lenmiyata said it so I still recommend it xD and kami no shizuku which zyta said, i have seen the drama so i can pretty much recommend it a little xD.... that is pretty much all the anime about drinking (full of drinking) that i can think of hmm...