Questionable Content - Questionable Content: New comics every Monday through Friday - One of the funniest comics I've read in a long time, its updated every week day.
Applegeeks - Applegeeks 3.0 - Read this on a whim, really really funny Nerd comic.
Queen of Wands - Queen of Wands - Its finished its run, but its still up there for people to read. An excellent story about 3 roommates.
Questionable Content is still my pick of the litter. Its original, funny, and has very detailed stories for each of the characters. The art work is amazing (Well, it gets amazing, the beginning kinda sucked, but the artist gets better and better with each comic.)