How ... ironic? Wow, that actually made me laugh, it was so funny. Yeah - it wasn't InnerHell that said that. Redirect that to the person who posted after InnerHell.
Still, the logical arguments against the android theory still apply.
Still, the "show" part you said was fact can be contended as well. For example, the wasteland Schwartzwald found the Big Duo in. There is sunlight there.
The significance of that is simple. The stagelights above Paradigm City are only applicable there. That means the show can't exist outside Paradigm City, and yet, we see that it clearly does.
There are other arguments I could present against the show theory, but I'm going to let up since I was wrong about something very fundamental not that long ago.
... I did mention there were Judeo-Christian themes in the Big O, right? Well, the most obvious one is this.
40 years - 40 days and 40 nights
"The world destroyed by a cataclysm. The power of God wielded by man. Giant robots run amok, everything is a lie."
- Gordon Rosewater
In religious history, 'Cataclysm' refers specifically to Noah's flood. In popular culture, it has been taken to mean any great disaster which causes change, but the word originated from the Bible story.
We thus have two correlating bonds between Noah's Flood and Paradigm City. In this sense, it isn't too hard to think of Paradigm City as an "ark" engineered to save mankind.